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Transient Hypogammaglobulinemia of Infancy Five New Cases, Review of the Literature and Redefinition
Author(s) -
DRESSLER F.,
PETER H. H.,
MÜLLER W.,
RIEGER C. H. L.
Publication year - 1989
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1989.tb11141.x
Subject(s) - hypogammaglobulinemia , medicine , immunodeficiency , pediatrics , immunology , antibody , immune system
ABSTRACT. The clinical and immunological data of 5 patients with transient hypogammaglobulinemia of infancy (THI) are presented and compared to published data. In THI, there is a distinction between patients who can mount a specific immune response, by producing specific antibodies to bovine serum albumin, diphtheria toxin, and isohemagglutinins, and patients with more severe forms of immunodeficiency. With only 5 reported cases of THI in 11 years and analysis of more than 8000 sera, our data support the notion that THI is a relatively rare disorder. THI can only be diagnosed with certainty in retrospect, although the ability to mount an active, specific immune response is a strong indicator for the diagnosis. We propose a more accurate definition of THI to help avoid clinical misjudgement.