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Response to Growth Hormone‐Releasing Hormone as Evidence of Hypothalamic Defect in Optic Nerve Hypoplasia
Author(s) -
LEAF A. A.,
ROSS R. J. M.,
JONES R. B.,
BESSER G. M.,
SAVAGE M. O.
Publication year - 1989
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1989.tb11104.x
Subject(s) - medicine , optic nerve hypoplasia , endocrinology , hypoplasia , optic nerve , hormone , growth hormone , hypothalamus , hypothalamic disease , anatomy , hypogonadotropic hypogonadism
. Hypothalamic‐pituitary function was studied in four children with Optic Nerve Hypoplasia (ONH). All were found to be growth hormone deficient when provoked with glucagon or insulin induced hypoglycaemia (ITT), but did respond to bolus injection of GHRH. This indicates a primary hypothalamic defect. Virtual absence of pituitary tissue on high resolution CT scan explained the poor response of one child. One child has shown an excellent response to treatment with subcutaneous GHRH, which is physiologically the most appropriate treatment for this condition.