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Differentiated Follicle‐Derived Thyroid Carcinoma in Children
Author(s) -
LAMBERG B.A.,
KARKINENJÄÄSKELÄINEN MARKETTA,
FRANSSILA K. O.
Publication year - 1989
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1989.tb11102.x
Subject(s) - medicine , follicular phase , thyroid , thyroid carcinoma , thyroglobulin , carcinoma , gastroenterology , radiation therapy , thyroidectomy , surgery
. Fifteen patients, 11 females and 4 males, aged 4–16 years with follicle‐derived differentiated thyroid carcinoma treated at the Helsinki University Central Hospital during 1953 through 1984 are reported. Histologically 13 carcinomata were papillary, 1 follicular and 1 was suspected to be follicular carcinoma (atypic adenoma). Eleven (73%) had cervical lymphnode metastases and 4 (25%) pulmonary metastases as well. All patients were initially operated on; total thyroidectomy was performed in 11 and subtotal in 4 patients. In 5 patients there was invasion into the thyroid capsule, perithyroid tissues and blood vessels; 4 patients with pulmonary metastases belonged to this group. Postoperatively 5 patients received radioactive iodine, 4 patients external irradiation to the neck and 6 were given both types of radiation. Pulmonary metastases were treated with radioactive iodine. The patients have been given suppressive doses of thyroxine. The follow‐up ranged from 3.5 to 33 years. One patient with extensive pulmonary metastases died 6 years after the initial treatment, all others are still alive. Twelve patients have been followed for 9 to 33 years, in 10 serum thyroglobulin was determined. Tg was undetectable in 9 patients when measured during thyroxin therapy; in 1 patient followed for 33 years, the dose was not suppressive, and there were no signs of disease and Tg in the normal range. In 2 patients Tg could not be determined but they had no signs of disease 18 and 22 years after initial treatment. It is, therefore, presumed that these patients, forming 80% of the material, are cured. Two patients followed for 3.5 years are still under treatment. Differentiated thyroid carcinoma in children should be treated by adequate surgery and postoperative therapy with radioactive iodine.