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Drug Binding Properties of Neonatal Albumin
Author(s) -
BRODERSEN R.,
HONORÉ B.
Publication year - 1989
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1989.tb11089.x
Subject(s) - albumin , diazepam , medicine , plasma protein binding , warfarin , serum albumin , pharmacology , atrial fibrillation
. Neonatal and adult albumin was isolated by gel chromatography on Sephacryl 5–300, from adult and umbilical cord serum, respectively. Binding of monoacetyl‐diamino‐diphenyl sul‐fone, warfarin, sulfamethizole, and diazepam was studied by means of equilibrium dialysis and the binding data were analyzed by the method of several acceptable fitted curves. It was found that the binding affinity to neonatal albumin is less than to adult albumin for monoacetyl‐diamino‐diphenyl sulfone and warfarin. Sulfamethizole binding to the neonatal protein is similarly reduced when more than one molecule of the drug is bound per albumin molecule, and binding of the first sulfamethizole molecule is possibly reduced as well. Diazepam binds with equal affinity to the fetal and adult proteins. Among the two main albumin drug‐binding functions, for warfarin and diazepam, the former is thus compromised in the newborn infant while the diazepam binding function is at the adult level.