Premium
Plasma Amino Acids in Relation to Metabolic Control in Insulin‐Dependent Diabetic Children
Author(s) -
HAGENFELDT L.,
DAHLQUIST G.,
PERSSON B.
Publication year - 1989
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1989.tb11070.x
Subject(s) - ketone bodies , medicine , phenylalanine , endocrinology , tyrosine , amino acid , metabolic control analysis , insulin , hemoglobin , arginine , methionine , proteolysis , alanine , biochemistry , metabolism , enzyme , biology
. The influence of metabolic control (estimated by blood glucose, 3‐hydroxybutyrate and glycosylated hemoglobin levels) on plasma amino acids was determined in a group of 56 insulin‐dependent diabetic children. A multiple correlation analysis revealed significant positive partial correlations between most amino acids and blood glucose. Alanine, methionine, tyrosine, phenylalanine and arginine showed negative partial correlations to the 3‐hydroxybutyrate level. The results are consistent with the postulate that ketone body inhibition of muscle proteolysis is one of the factors regulating substrate flows during insulin deficiency.