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Hyperferritinemia in Malignant Histiocytosis, Virus‐Associated Hemophagocytic Syndrome and Familial Erythrophagocytic Lymphohistiocytosis
Author(s) -
ESUMI N.,
IKUSHIMA S.,
TODO S.,
IMASHUKU S.
Publication year - 1989
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1989.tb11068.x
Subject(s) - medicine , histiocyte , hemophagocytic lymphohistiocytosis , histiocytosis , ferritin , malignant histiocytosis , virus , immunology , pathology , virology , disease
. Data on 28 patients with malignant histiocytosis (MH), fourteen patients with virus‐associated hemophagocytic syndrome (VAHS) and two patients with familial erythrophagocytic lymphohistiocytosis (FEL) were collected from 21 hospitals in Japan to study the serum ferritin levels and clinical features. At diagnosis, the serum ferritin values were a median of 3000 ng/ml (range, 59–270000 ng/ml) in MH and 10500 ng/ml (range, 44–68600 ng/ml) in VAHS/FEL. Clinical signs and symptoms were not substantially different between MH and VAHS/FEL. Thus, serum ferritin markedly increased in the majority of MH/VAHS/FEL patients and should be a useful marker of disease activity in either neoplastic or reactive histiocytic proliferative disorders.