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Increased Faecal Alpha‐1 ‐Antitrypsin Excretion in Children with Persistent Diarrhoea Associated with Enteric Pathogens
Author(s) -
BHAN M. K.,
KHOSHOO V.,
CHOWDHARY D.,
JAIN R.,
RAJ P.,
JAYASHREE S.,
KUMAR R.
Publication year - 1989
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1989.tb11067.x
Subject(s) - medicine , giardia lamblia , giardia , gastroenterology , excretion , failure to thrive , diarrhea , feces , salmonella , microbiology and biotechnology , biology , veterinary medicine , bacteria , pathology , genetics
. The random faecal alpha‐1‐antitrypsin (AT) excretion (mg/g dry weight of stool) was measured in 30 infants and children (mean age 10.8±8 mo.) with protracted diarrhoea (duration ≥21 days) and failure to thrive and 27 normally nourished children (mean age 13±4.5 mo.) without any gastrointestinal symptoms in the preceding 12 weeks. The associated factors in patients with protracted diarrhoea and their mean faecal AT during active disease and 3–4 weeks after recovery were as follows: Enteropathogenic E. coli 5 (7.9±5.5; 3.2±0.6), Giardia lamblia 4 (3.9±1.8; 2.5±0.7), Salmonella typhimurium 3 (4.0±0.2; 3.8±0), secondary carbohydrate intolerance 11 (2.5±0.9; 2.4±0.8), and others 7 (3.4±0.7; 3.0±0.5), respectively. Of all the patients with protracted diarrhoea the mean AT in the E. coli , Giardia and Salmonella groups were significantly higher than the mean in the control group (2.1±0.8) and following treatment and recovery the values were comparable to that in the controls. All the 6 patients with very high faecal AT (> mean + 3 SD of controls) were associated with an enteric pathogen.