Premium
Dysfunction of the Monocyte‐Macrophage System in the Idiopathic Minimal Change Nephrotic Syndrome
Author(s) -
ESTEVEZ M. E.,
VOYER L. E.,
CRAVIOTTO R. J.,
BALLART I. J.,
GOICOA M. A.,
PALACIOS F.,
QUADRI B.,
CORTI S.,
WAINSTEIN R. E.,
SEN L.
Publication year - 1989
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1989.tb10892.x
Subject(s) - medicine , monocyte , nephrotic syndrome , phagocytosis , immunology , lymphocyte , peripheral blood , macrophage , antibody , lytic cycle , biology , biochemistry , in vitro , virus
. We studied the function of phagocytes and the distribution of lymphocyte subpopulations in 23 patients with Idiopathic Minimal Change Nephrotic Syndrome. All the patients were in relapse at the time of the study. The latter was performed before specific therapy was started. Our control group consisted of 26 normal children who were studied while undergoing routine analysis prior to plastic surgery. Polymorphonuclear leukocytes from the patients showed no alterations in their ability to ingest and to kill Candidas. On the contrary, peripheral blood monocytes had a normal phagocytic function with a decreased candidacidal activity when compared to normal controls (p<0.001). No correlation was found between serum immunoglobulin levels and the monocyte lytic function. The absolute number of B lymphocytes was significantly increased