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Serum Antibodies to Cow's Milk Proteins in Pediatric Inflammatory Bowel Disease: Crohn's Disease vs. Ulcerative Colitis
Author(s) -
LERNER AARON,
ROSSI THOMAS M.,
PARK BYUNG,
ALBINI BORIS,
LEBENTHAL EMANUEL
Publication year - 1989
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1989.tb10891.x
Subject(s) - ulcerative colitis , medicine , inflammatory bowel disease , antibody , crohn's disease , immunology , casein , gastroenterology , disease , serum albumin , colitis , bovine serum albumin , biology , food science
. Serum antibodies to five cow's milk proteins, α‐casein, bovine serum albumin (BSA), β‐lac‐toglobulin A and B (BLG‐a, BLG‐b) and α‐lactalbumin (ALA) were investigated in young patients with inflammatory bowel disease, 56 with Crohn's disease (CD), 24 with ulcerative colitis (UC). IgG antibodies against BSA and BLG‐a and ‐b were higher in Crohn's disease patients as compared to those with ulcerative colitis and controls. The IgG anti‐BSA were higher in the group of CD patients with higher score of disease activity. Additionally, IgA antibodies to a‐casein were higher in CD and UC compared to control. These findings may be due to increased uptake of dietary antigens or enhanced immunological response occurring in CD patients.