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Oestrogen Therapy in Turner's Syndrome
Author(s) -
KASTRUP K.W.
Publication year - 1988
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1988.tb10799.x
Subject(s) - medicine , turner syndrome , endocrinology , somatomedin , turner's syndrome , bone age , growth hormone , hormone
Oestradiol stimulates growth and development in Turner's syndrome. Previous results with low‐dose oestradiol on growth rate are reviewed. The effect of oestradiol in low concentrations on somatomedin generation, GH secretion and directly on osseous tissue, may explain the growth response. The observations presented here of 35 girls treated with 17‐β‐oestradiol demonstrated a definite increase in growth rate in the first year of therapy. Bone maturation was accelerated, but a reduction in final height was not found.