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Venous Thrombosis Associated with Lupus Anticoagulant and Anticardiolipin Antibodies
Author(s) -
PELKONEN P.,
SIMELL O.,
RASI V.,
VAARALA O.
Publication year - 1988
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1988.tb10750.x
Subject(s) - medicine , lupus anticoagulant , anti nuclear antibody , thrombosis , pulmonary embolism , connective tissue disease , systemic lupus erythematosus , lupus erythematosus , venous thrombosis , immunology , systemic disease , autoimmune disease , antibody , disease , immunopathology , autoantibody
. We describe deep vein thrombosis associated with lupus anticoagulant and anticardiolipin antibodies in three children aged 10 to 14 years. One of them also had arterial thromboses. None of the patients had systemic lupus erythematosus when the thrombosis first occurred, but one fulfilled the criteria for systemic lupus erythematosus 3 years later. At presentation all had symptoms suggestive of pulmonary embolism and evidence of an autoimmune disease: Addison's disease in one, anti‐DNA or antinuclear antibodies in all three, and a positive Coombs' test in two. Two of the three gave a false‐positive test for syphilis. In the patient with systemic lupus erythematosus recurrent thrombocytopenia and severe haemolytic anaemia necessitated splenectomy. A child should be tested for lupus anticoagulant or anticardiolipin antibody if venous or arterial occlusion occurs without a known predisposing cause, or if there is pulmonary embolism or symptoms or laboratory findings suggestive of a connective tissue disease.