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Neurologic Sequelae Following Interferon Therapy of Juvenile Laryngeal Papilloma
Author(s) -
VESIKARI TIMO,
NUUTILA AULI,
CANTELL KARI
Publication year - 1988
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1988.tb10718.x
Subject(s) - medicine , juvenile , papilloma , pathology , biology , genetics
. Human leukocyte interferon at doses from 2 million units every two days to 3 million units daily was given to a 2‐year‐old boy for the treatment of recurrent juvenile laryngeal papilloma. After 7 months of treatment the child developed spastic diplegia, which persisted despite the discontinuation of interferon therapy. The clinical picture was consistent with an upper motor neuron lesion; no evidence of peripheral neuropathy was found.