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Salt and Water Homeostasis during Oral Rehydration Therapy in Neonates and Young Infants with Acute Diarrhoea
Author(s) -
MARIN L.,
SÖKÜCÜ S.,
GÜNOZ H.,
SANÉR G.,
NEYZI O.,
ZETTERSTRÖM R.
Publication year - 1988
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1988.tb10594.x
Subject(s) - medicine , homeostasis , dehydration , sodium , high sodium , hypernatremia , oral rehydration therapy , diarrhea , acute diarrhea , pediatrics , gastroenterology , population , biochemistry , chemistry , environmental health , organic chemistry , blood pressure , health services
. The clinical response and changes in water and salt homeostasis were studied daring oral rehydration therapy (ORT) with a solution containing 90 mmol sodium per I (ORS 90 ) in 9 infants less than 2 months old (range 2–60 days). Two infants were still dehydrated 36 hours after starting ORT and were excluded from the study. Fluid was retained more rapidly and also to a larger extent than in infants of the same age treated with a solution with a sodium concentration of 60 mmol/l (ORS 60 ). The stool sodium output was higher than that found previously in infants of the same age treated with ORS 60 . We conclude that during ORT the gut plays an active role in the regulation of salt homeostasis. When the sodium intake is high the percentage of sodium remaining unabsorbed is higher than when the intake is low. This mechanism reduces the risk of hypematremia in young infants treated with ORS 90 . The study thus demonstrates that ORS 90 is effective and also seems to be safe in the treatment of neonates and young infants with dehydration secondary to diarrhoea if fluid intake is kept around 200 ml/kg/day during the rehydration period.