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Concentrations of C1q, Factor B, Factor D and Properdin in Healthy Children, and the Age‐Related Presence of Circulating C1r‐C1s Complexes
Author(s) -
PRELLNER K.,
SJÖHOLM A. G.,
TRUEDSSON L.
Publication year - 1987
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1987.tb17268.x
Subject(s) - properdin , medicine , complement factor b , incidence (geometry) , ontogeny , risk factor , immunology , endocrinology , physiology , antibody , complement system , physics , optics
. The concentrations of C1q, factor B, factor D and properdin were determined in healthy children belonging to various age groups of one through five years of age. All concentrations were found to be age‐dependent, though they varied from one component to another with regard to ontogenetic pattern. Thus, the concentrations of factor B were high, and those of factor D low throughout the age range studied. C1q and properdin levels were lowest in the younger children, who also showed a failry high incidence of C1r‐C1s complexes in excess of C1q. Since the concentrations of C1q are influenced by those of IgG, the presence of C1r‐C1s complexes might partly have reflected maturation of immunoglobulin synthesis during ontogeny.