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The Chronically Reserpinized Rat Disturbed Energy Metabolism in the Submandibular Gland
Author(s) -
BARDO A.,
MÜLLER R. M.,
CEDER O.,
ROOMANS G. M.,
KOLLBERG H.
Publication year - 1987
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1987.tb17108.x
Subject(s) - medicine , endocrinology , citrate synthase , creatine , malate dehydrogenase , submandibular gland , fructose , lactate dehydrogenase , enzyme , chemistry , biochemistry
. Some of the enzymes and metabolites of the glyconeogenetic pathway, ATP and creatine phosphate were investigated in the submandibular gland of reserpinized rats, and compared to those of control rats. Decreased activities of malic enzyme (p<0.005) and glucose‐6‐phosphatase (p<0.001) were found, while the activities of fructose‐1,6‐diphosphatase and malate dehydrogenase were not significantly changed. No activity of pyruvate carboxylase or phosphoenolpyruvate carboxylase was detected. Oxaloacetate ( p <0.01), malate ( p <0.005) and citrate ( p <0.005) were found in decreased concentrations and fructose‐6‐phosphate in increased concentration in the submandibular glands of reserpinized rats. Decreased concentration of ATP ( p <0.01) was found whereas the concentration of creatine phosphate was increased ( p <0.05). The activity of creatinephosphokinase was decreased ( p <0.005). These findings show a disturbance of high‐energy phosphate compounds content and a possible acidosis in the submandibular gland of this animal model for cystic fibrosis.