Premium
C2 Deficiency, Moderately Low lgG2 Concentrations and Lack of the G2m(23) Allotype Marker in a Child with Repeated Bacterial Infections
Author(s) -
SJÖHOLM A. G.,
HALLBERG T.,
OXELIUS V.A.,
HAMMARSTRÖM L.,
SMITH C. I. E.,
LINDGREN F.
Publication year - 1987
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1987.tb10514.x
Subject(s) - allotype , medicine , immunology , meningitis , pneumonia , otitis , antigen , pediatrics , surgery
. C2 deficiency was demonstrated in an 11‐year‐old boy with a past history of recurrent purulent otitis media, pneumonia, H. influenzae meningitis and S. pneumoniae septicaemia. The major histocompatibility complex haplotypes present, A10, B18, DR2, BF*S, C2*QO, C4*A4, C4*B2 and A28, B18, DR2, BF*S, C2*QO, C4*A4, C4*B2 , were in accord with previous observations in C2 deficiency. The concentrations of C1q, C5, factor B and factor D were in the low normal range and the hemolytic activity of the alternative pathway was slightly decreased. In addition, the patient showed moderately low IgG2 concentrations and lacked the IgG2 subclass marker G2m(23). The findings indicate that the patient's susceptibility to bacterial infections may be due to C2 deficiency in combination with the presence of an IgG allotype associated with impaired antibody responses to carbohydrate antigens.