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Evidence for Transient Peripheral Resistance to Parathyroid Hormone in Premature Infants
Author(s) -
KRUSE K.,
KÜSTERMANN W.
Publication year - 1987
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1987.tb10425.x
Subject(s) - medicine , endocrinology , parathyroid hormone , osteocalcin , creatinine , hydroxyproline , bone remodeling , alkaline phosphatase , urinary system , calcium , chemistry , enzyme , biochemistry
. Serum immunoreactive parathyroid hormone (iPTH), ionized calcium, the urinary cyclic AMP/creatinine ratio (cAMP/Cr) and some indices of bone turnover (alkaline phosphatase (AP), serum osteocalcin, and the urinary total hydroxyproline/creatinine ratio (OH‐P/Cr)) were measured in 26 preterm infants during the first 4 weeks of life. Despite of stimulated parathyroid gland activity cAMP/Cr, AP, osteocalcin and OH‐P/Cr were low during the first week. Thereafter iPTH decreased, whereas cAMP/Cr, and the indices of bone turnover increased, reaching high‐normal values (in comparison to full‐term infants) during the second and third week of life. Serum iPTH was negatively correlated to cAMP/Cr in the first week ( r =–0.61, p <0.01), whereas the relationship became positive during the second ( r =0.47, p <0.05) and third ( r =0.54, p <0.05) week of life indicating maturation of the renal response to PTH. The study supports the concept that in premature infants a transient pseudohypo‐parathyroid‐like state is present during the first week of life reflecting an immaturity of renal and possibly bone response to PTH. This may be an etiological factor in hypocalcemia of prematurity.