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Ductus Closure in Preterm Infants Effects on Cerebral Hemodynamics
Author(s) -
LUNDELL B. P. W.,
SONESSON S.E.,
COTTON R. B.
Publication year - 1986
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1986.tb10401.x
Subject(s) - medicine , ligation , blood flow , hemodynamics , cerebral blood flow , constriction , anesthesia , ductus arteriosus , cardiology , diastole , blood pressure
. Idracranial arterial blood flow velocities were studied before and after ductus closure by smgery ( n =8) and indomethacin ( n =10) in very low birth weight infants. Blood flow velocities were measured non‐invasively through the fontanel with a pulsed Doppler velocimeter. Ligation of the ductus was associated with a 62% increase in mean flow velocity 24 hours after surgery, mainly secondary to increased diastolic flow velocity. Iodomethacin (0.2 nig/kg i.v.) induction of ductus constriction was associated with a 36% decrease of mean flow velocity one hour after administration. At 24 hours, the intracranial blood flow velocity had returned to the pretreatment level but was still significantly lower than after ligation. Ductus dosure is associated with marked changes in cerebral hemodynamics. Ligation causes increased arterial blood flow velocities and indomethacin administration seems to reduce Mood flow velocities to the brain.