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Experimental Research on IGF‐1
Author(s) -
SKOTTNER A.,
FRYKLUND L.,
HANSSON H.A.
Publication year - 1986
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1986.tb10376.x
Subject(s) - regeneration (biology) , endocrinology , medicine , bovine somatotropin , receptor , priming (agriculture) , adipose tissue , in vitro , immunohistochemistry , hormone , growth hormone , cell division , pancreatic islets , insulin , islet , microbiology and biotechnology , cell , biology , biochemistry , botany , germination
. IGF‐1 has been produced by recombinant DNA technology; the host cell is a yeast. Studies in hypophysectomized rats show that IGF‐1 has little growth promoting effect unless given by infusion at high doses, and priming with bovine growth hormone did not produce any potentiation. In vitro studies reveal that IGF‐1 cross‐reacts with the insulin receptor on adipose cells. Immunohistochemical studies have revealed high IGF‐1 immunoreactivity in proliferating and differentiating cells in the testes, lymphoid organs and pancreatic islets and particularly in regenerating nerves. Local application of IGF‐1 may stimulate regeneration in damaged peripheral nerves.