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Lipid‐A‐Antibodies–Indicators for the Risk of Renal Scarring in Children with Urinary Tract Infection
Author(s) -
MISSELWITZ J.,
NEUBERT H.,
HORN A.,
ERLER W.
Publication year - 1986
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1986.tb10327.x
Subject(s) - medicine , urinary system , scars , antibody , kidney , risk factor , immunology , gastroenterology , surgery
. The levels of IgG‐ and IgM‐antibodies against lipid A were determined by an ultramicro‐ELISA in 54 children between 2 months and 13 years of age with non‐obstructive urinary tract infections at the onset of the infection and subsequently after 3, 6 and 12 months. Children older than 2 years who later developed renal scarring as shown by intravenous pyelo‐grams had higher levels of IgG antibodies than those without scars. This correlation was not found in children younger than 2 years of age. IgM‐anribody levels did not correlate with the risk of scar formation. We conclude that the IgG‐antibody level against lipid A is a useful indicator for early recognition of children over the age of two years who will later develop renal scars. The ultramicro‐ELISA technique makes screening for children at risk possible at a low cost.