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Neonatal Fat Digestion and Lingual Lipase
Author(s) -
SMITH L. J.,
KAMINSKY S.,
D'SOUZA S. W.
Publication year - 1986
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1986.tb10316.x
Subject(s) - lipase , medicine , triglyceride , digestion (alchemy) , zoology , hydrolysis , bottle , stomach , food science , chromatography , biochemistry , chemistry , enzyme , biology , cholesterol , mechanical engineering , engineering
. Lingual lipase (IX) activity, pH, and products of fat hydrolysis were determined in gastric aspirates from preterm infants who received formula milk feeds by a nasogastric tube. In 1‐hourly ( n =9), 2‐houriy ( n =8) and 3‐hourly ( n =9) fed infants LL activity increased to reach its maximum value at 60, 90, and 120 min respectively after the feeds, and gastric pH levels fell from about 6.0 to <3.5. There was a reduction in triglyceride content to 50% of the initial value, measured immediately after a feed, and the products of hydrolysis were mainly di‐glycerides and FFA. In a subsequent study 3‐hourly fed infants ( n =8) had a tube feed followed by a bottle feed, and then a bottle feed followed by a tube feed on successive days (cross‐over). The LL activity observed after a bottle feed (mean maximal value 23.8 nmol FFA/ml/h) was significantly higher than after a tube feed (19.1 nmol FFA/ml/h). It is suggested that substantial triglyceride hydrolysis takes place in the stomach due to lingual lipase, and sucking seems to enhance enzyme production.