Premium
Age‐related Anti‐thyroid Antibodies and Thyroid Abnormalities in Turner Syndrome
Author(s) -
GERMAIN EMILY L.,
PLOTNICK LESLIE P.
Publication year - 1986
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1986.tb10285.x
Subject(s) - medicine , thyroid , anti thyroid autoantibodies , goiter , endocrinology , antibody , turner syndrome , titer , antibody titer , gastroenterology , immunology , autoantibody
. One hundred pediatric patients with Turner syndrome were studied to determine the correlation between the presence of anti‐thyroid antibodies with age and karyotype, and the value of anti‐thyroid antibody titers as predictors of subsequent thyroid abnormalities. (54 patients = 45,X; 46 = other karyotypes.) The frequency of positive titers of anti‐thyroid antibodies increased linearly with cumulative age. Anti‐parietal cell and anti‐adrenocortical cell antibodies were not increased in these patients (1.3 and 2.6% respectively). The ability to use positive anti‐thyroid antibody titers to predict the development of thyroid abnormalities increased from age 10 years and became statistically significant at ages 13‐17 years for the whole group as well as 45,X patients. None of the patients had clinical symptoms of thyroid dysfunction although 22% developed thyroid abnormalities, which included elevated TSH, low T 4 , and/or goiter.