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Evidence for Amino Acid Induced Cholestasis in Very‐low‐birth‐weight Infants with Increasing Enteral Protein Intake
Author(s) -
SENGER H.,
BOEHM G.,
BEYREISS K.,
BRAUN W.,
RAIHA N.
Publication year - 1986
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1986.tb10281.x
Subject(s) - medicine , cholestasis , enteral administration , bile acid , amino acid , parenteral nutrition , urine , endocrinology , low birth weight , birth weight , biochemistry , pregnancy , biology , genetics
. In the present investigation 32 very‐low‐birth‐weight (VLBW) infants fed at three different levels of protein intake (2.92 g/kg/d from human milk, 3.22 and 4.06 g/kg/d from formula) were studied at the mean age of 21 days. Serum total α‐amino nitrogen concentration correlated directly to total bile acid concentration. The serum and urine a‐amino nitrogen and the serum bile acid concentration correlated with protein intake. The increase in protein intake was accompanied by a concomitant decrease in the intraluminal bile acid concentration in the AGA infants. The results offer indirect evidence of decreased bile flow in YLBW‐infants on excessive oral protein intake. The cholestatic effect could be mediated by an increase in the plasma amino acid concentration.