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Neutralizing Activity in Human Milk Fractions against Respiratory Syncytial Virus
Author(s) -
LÆGREID A.,
OTNÆSS A.B. KOLSTø,
ØRSTAVIK I.,
CARLSEN K. H.
Publication year - 1986
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1986.tb10276.x
Subject(s) - medicine , titer , virus , neutralizing antibody , respiratory system , antibody , virology , immunoglobulin a , pneumovirinae , immunology , paramyxoviridae , immunoglobulin g , viral disease
. Neutralizing activity against respiratory syncytial virus (RSY) was measured in milk samples from 17 healthy women whose infants had an acute infection with respiratory syncytial virus (RSV) and from 27 women with healthy infants. All milk samples were obtained 2‐8 months post partum. Neutralizing activity was detected in 36 samples. No major difference in neutralizing titers was observed between the two groups, and the titers were low. RSV‐specific IgA was found in two samples, and RSV‐specific IgG in one sample. RSV‐specific IgM was not detected. In gel filtration studies, the neutralizing activity was eluted with an apparent molecular weight above 400 000. The neutralizing activity remained after removal of IgA by affinity chromatography. These findings suggest that both immunoglobulin and non‐im‐munoglobulin components in human milk can neutralize RSV.