Premium
GH Deficient Children Receiving GH Replacement Do not Grow during Intermittent Infectious Illness
Author(s) -
HERMANUSSEN M.,
GEIGERBENOIT K.,
SIPPELL W. G.
Publication year - 1986
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1986.tb10258.x
Subject(s) - medicine , growth hormone , human growth hormone , growth velocity , hormone , pediatrics
. Five growth hormone deficient children, aged 5.3 to 12.6 yrs, were measured regularly once or twice weekly by knemometry, a novel and noninvasive technique of accurate lower leg length measurement. The total period of observation was 40 months in the 5 children. During this time all children received replacement therapy with extractive human pituitary growth hormone 12 IU/m 2 /week by daily S.C. injections. 11 intermittent infectious illnesses occurred within the observation period of 40 months. During the infectious diseases a significant decrease of the mean lower leg growth velocity down to ‐0.012 mm/day was observed. During the following convalescent period (14 days) mean lower leg growth velocity rose up to +0.107 mm/day ( p < 0.001). Growth hormone substitution was not changed throughout the period of observation.