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Lactoferrin, C‐reactive Protein, α‐1‐Antitrypsin and Immunoglobulin GA in Cerebrospinal Fluid in Meningitis
Author(s) -
GUTTEBERG T. J.,
FLÆGSTAD T.,
JØRGENSEN T.
Publication year - 1986
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1986.tb10252.x
Subject(s) - lactoferrin , radial immunodiffusion , cerebrospinal fluid , meningitis , medicine , csf albumin , c reactive protein , latex fixation test , immunology , sepsis , immunodiffusion , microbiology and biotechnology , antibody , pathology , inflammation , biology , biochemistry , psychiatry
. Cerebrospinal fluid measurements of lactoferrin and α‐1‐antitrypsin showed significant elevation in bacterial meningitis in children. 8 of 10 lactoferrin values and 6 of 11 α‐1‐antitrypsin values were above the upper range of controls. Both proteins correlated well with the total number of leukocytes in the cerebrospinal fluid. C‐reactive protein, measured by either agglutination or radial immunodiffusion in the cerebrospinal fluid, failed to demonstrate any asefulness in diagnosing bacterial meningitis. Neither elevated serum C‐reactive protein in cases of bacterial meningitis, nor sepsis, gave detectable concentrations of C‐reactive protein in the cerebrospinal fluid.