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A Comparative Study of the Mouth to Caecum Transit Time in Children and Adults Using a Weight Adapted Lactulose Dose
Author(s) -
VREUGDENHIL G.,
SINAASAPPEL M.,
BOUQUET J.
Publication year - 1986
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1986.tb10234.x
Subject(s) - lactulose , medicine , caecum , lactose , hydrogen breath test , gastroenterology , transit time , age groups , zoology , food science , breath test , demography , chemistry , sociology , transport engineering , engineering , biology , helicobacter pylori
. Mouth to caecum transit time (M.C.T.T.) was assessed in 41 subjects divided into 3 age groups (0‐1 year, 1‐4 years and 22‐27 years) with the hydrogen breath test (H.B.T.) using lactulose as the hydrogen source (250 mg/kg; minimal dose 1.5 g in a 10% aqueous solution). The M.C.T.T. remained constant from the second month of age. In children under 1 year of age a high percentage of non‐responders was found compared to the older age‐groups. In 8 adults two test‐substrates, pure lactulose (Legendal®, L) and a mixture of lactulose, lactose and galactose (Duphalac®, D) were compared. There was no significant difference in M.C.T.T., mean hydrogen production and clinical symptoms using D or L as substrate. We conclude that the H.B.T. using a relative dosage is a suitable test for children, but under the age of 1 year it is less useful because of the high percentage of non‐responders. Because of the relation between body height and small bowel length the results suggest an increase in the velocity of the intestinal content with age.