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HLA Antigens, Jejunal Morphology and Associated Diseases in Children with Dermatitis Herpetiformis
Author(s) -
KÁRPÁTI S.,
KÓSNAI I.,
VERKASALO M.,
KUITUNEN P.,
SIMON ZS.,
KOSKIMIES S.,
REUNALA T.,
GYÓDI É.,
TÖRÖK É.
Publication year - 1986
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1986.tb10202.x
Subject(s) - dermatitis herpetiformis , medicine , atopic dermatitis , human leukocyte antigen , family history , villous atrophy , atopy , dermatology , atrophy , antigen , immunology , allergy , coeliac disease , disease
. Forty‐five Hungarian and Finnish children from 1.5 to 15 years with dermatitis herpetiformis were studied for HLA antigens, jejunal morphology on gluten‐containing diet and associated diseases in the patients and their relatives. A strong association with HLA‐B8 was found in patients of both nationalities, the relative risks were 12.8 and 9.6, respectively. The Hungarian patients were also typed for HLA‐DR locus, and an association with DR3 but not with DR7 was observed. Patients with subtotal villous atrophy had slightly more often HLA‐B8 and DR3 than those with milder intestinal lesions. Atopic eczema occurred in 20 % of the patients and family history of atopy seemed to have an inverse correlation with HLA‐B8 and DR3.