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Anti‐D in a‘D Positive’Mother Giving Rise to Severe Haemolytic Disease of the Newborn
Author(s) -
ØSTGÅRD P.,
FEVANG F.,
KORNSTAD L.
Publication year - 1986
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1986.tb10178.x
Subject(s) - haemolytic disease , medicine , antigen , serology , rh blood group system , disease , epitope , hemolytic disease of the newborn (abo) , immunology , pregnancy , pediatrics , antibody , fetus , genetics , biology
.An Rh positive woman having the Rh(D) variant designated D VI formed a potent anti‐D which caused a severe haemolytic disease in the infant. The infant received three exchange transfusions within the first 21 hours after delivery and, because of a ‘late anaemia’, three additional blood transfusions during the first 3 months of life. The authors point out the distinction between D variant antigens, where certain epitopes of the D antigen are lacking, and qualitatively normal D antigens with a reduced reactivity, D u . Women with D variant antigens should be subject to the same antenatal serological control as those who are Rh(D) negative, and if they form anti‐D the infant should be controlled as in other cases where haemolytic disease of the newborn is suspected.