Premium
Antibodies to Staphylococcal Teichoic Acid and Alpha Toxin in Patients with Cystic Fibrosis
Author(s) -
ERICSSON A.,
GRANSTRÖM M.,
MÖLLBY R.,
STRANDVIK B.
Publication year - 1986
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1986.tb10170.x
Subject(s) - teichoic acid , staphylococcus aureus , cystic fibrosis , medicine , microbiology and biotechnology , antibody , toxin , staphylococcal infections , micrococcaceae , antigen , staphylococcus , immunology , bacteria , biology , genetics
.Enzyme‐linked immunosorbent assay (ELISA) was used for IgG antibody determination to teichoic acid and a ‐toxin from Staphylococcus aureus in 65 patients with cystic Fibrosis (CF). In patients chronically colonized with S. aureus , elevated titres to teichoic acid were found in 13/35 (37%) patients, to a ‐toxin in 12/35 (34%) and to either antigen in 18/35 (51%). Patients with elevated titres to teichoic acid had a significantly lower X‐ray score than patients with normal titres. The highest titres against both teichoic acid and a ‐toxin were seen in patients not receiving optimal treatment. These findings suggest that staphylococci contribute to the tissue damage in CF and that the determination of antibodies especially to staphylococcal teichoic acid might be of value in the diagnosis and management of staphylococcal infections in patients with CF.