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Hyperfunctioning Thyroid Nodules in Children and Adolescents
Author(s) -
DE LUCA F.,
CHAUSSAIN J. L.,
JOB J. C.
Publication year - 1986
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1986.tb10167.x
Subject(s) - medicine , euthyroid , subclinical infection , thyroid , nodule (geology) , adenoma , hormone , thyroid nodules , endocrinology , paleontology , biology
.Eight children and adolescents, seven female and one male, aged 7.1 to 15.0 years, referred over a 12‐year period for a solitary mass in an otherwise normal thyroid gland, exhibited a hyperfunctioning nodule on thyroid scintiscan. Tracer uptake in the surrounding thyroid tissue was reduced or completely suppressed, but could be restored after TSH stimulation. Only one patient had mild clinical hyperthyroidism with normal T4 but increased T3 serum levels and blunted TSH responsiveness to TRH. A similar hormonal pattern suggestive of subclinical hyperthyroidism was found in three other subjects who were clinically euthyroid. One patient initially euthyroid progressed to subclinical hyperthyroidism two years later. In the whole group a significant negative relationship was found between serum T3 level and TRH‐stimulated TSH peak (r= ‐0.829, p<0.02). All the patients underwent selective surgery after a 3‐month to 2‐year period of follow‐up. Microscopic examination was consistent with adenoma in seven patients, while in one case a well‐encapsulated papillary adenocarcinoma was found. Though hyperfunctioning nodules are seldom malignant, their surgical removal must be recommended when they become thyrotoxic, exceed 3 cm or show progressive enlargement.