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Estimation of Glomerular Filtration Rate in Children Using 99m‐Technetium DTPA
Author(s) -
YAP H. K.,
SUNDRAM F. X.,
YIP W. C. L.,
TAY J. S. H.,
ANG E. S.,
TOH H. J.,
JOSEPH V. T.,
SAW A. H.
Publication year - 1985
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1985.tb11033.x
Subject(s) - renal function , medicine , creatinine , plasma clearance , urology , clearance , technetium , technetium 99m , filtration fraction , inulin , renal physiology , nuclear medicine , scintigraphy , chemistry , renal blood flow , pharmacokinetics , biochemistry
. The usefulness of radionuclide imaging studies with 99m‐technetium diethylenetriaminepen‐taacetic acid (Tc‐DTPA) for quantitating the glomerular filtration rate (GFR) in children was studied. This was compared to the conventional methods for measuring GFR using 51‐chromium‐EDTA clearance (Cr‐EDTA), creatinine clearance and a height/plasma creatinine formula. In the 22 children studied, the correlation coefficient between renal uptake of DTPA and Cr‐EDTA was 0.90 ( p <0.001). In contrast, there was a poorer correlation between Cr‐EDTA and creatinine clearance ( r =0.69) or the derived GFR using height/creatinine formula ( r =0.83). The regression line between Tc‐DTPA uptake and Cr‐EDTA clearance was used to derive a formula for calculating the predicted GFR. This was tested in 10 additional children, and the correlation between the predicted GFR and measured GFR (using Cr‐EDTA clearance studies) was 0.92 ( p <0.001). Quantitative estimation of the GFR during renal imaging studies is a feasible and convenient method of assessing renal function.