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Cerebrospinal Fluid C‐Reactive Protein in the Laboratory Diagnosis of Bacterial Meningitis
Author(s) -
MACFARLANE D. E.,
NARLA V. R.
Publication year - 1985
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1985.tb11029.x
Subject(s) - medicine , meningitis , streptococcus pneumoniae , cerebrospinal fluid , white blood cell , haemophilus influenzae , csf albumin , c reactive protein , microbiology and biotechnology , streptococcus , blood culture , microbiological culture , gram staining , immunology , klebsiella pneumoniae , staphylococcus aureus , bacteria , antibiotics , escherichia coli , surgery , biology , inflammation , genetics , biochemistry , gene
. Samples of cerebrospinal fluid from 112 cases of suspected meningitis were tested for the presence of C‐reactive protein (CRP), using a qualitative and quantitative slide test. Bacterial meningitis was confirmed in 34 patients, based on CSF and blood culture results, and/or elevated CSF white blood cell (WBC) count and typical biochemical profile. There were 8 patients with early onset, and 3 who had received prior antimicrobial therapy among the 5 neonates, 23 children, and 6 adults with bacterial meningitis. Organisms recovered from CSF, and/or blood, included Haemohilus influenzae 14, Streptococcus pneumoniae 9, Streptococcus group B 5, Staphylococcus aureus 2, E. coli 2 and Klebsiella penumoniae 1. Slide test was positive for CRP in 33 cases, giving a sensitivity of 97 % which compared favourably with elevated CSF protein 33 %, decreased CFS glucose 64.7 % CSF glucose/blood glucose