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Subclinical Thyroid Hormone Abnormalities in Type I Diabetic Children and Adolescents. Relationship to Metabolic Control
Author(s) -
DORCHY H.,
BOURDOUX P.,
LEMIERE B.
Publication year - 1985
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1985.tb10989.x
Subject(s) - medicine , subclinical infection , metabolic control analysis , endocrinology , hormone , thyroid , pediatrics , thyroid hormones , diabetes mellitus
. The serum levels of thyroid hormones and thyroid stimulating hormone were compared in 64 type I diabetic children and adolescents without ketosis and in 28 age matched normal subjects. Only T 3 levels were significantly different in the diabetic patients (2.38±0.41 nmol/1) than in controls (2.64±0.52 nmol/1) (p<0.01) confirming the existence of the‘low T 3 syndrome’in diabetic children. A negative correlation was found between T 3 and blood glucose as well as glycosylated haemoglobin suggesting that short‐term hyperglycaemia could regulate T 3 concentration. Thyroid function was not different in diabetic children with or without thyroid antibodies. We conclude that serum T 3 , level is influenced by the degree of metabolic control and that thyroid function in diabetic children should be assessed by the measurement of the serum concentration of T 4 , FT 4 and TSH.