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Mitogenic Activity and Epidermal Growth Factor Content in Human Milk
Author(s) -
JANSSON L.,
KARLSON F. A.,
WESTERMARK B.
Publication year - 1985
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1985.tb10959.x
Subject(s) - medicine , epidermal growth factor , food science , receptor , chemistry
. The concentration of epidermal growth factor (EGF) was determined by radioimmunoassay in colostral and mature human milk. The content of EGF in colostral milk was 25‐38 ng/ml compared to 5.2‐11.5 ng/ml in samples of mature milk. The radioimmunoassayable EGF content in mature milk was not influenced by pasteurization and EGF was detected in a preparation of human milk protein at a concentration similar to that found in mature milk. The growth promoting activity in human milk measured by 3 H‐thymidin incorporation in human fibroblasts was higher in colostral milk (stimulated incorporation 8.7.fold) than in mature milk (stimulated incorporation about 7‐fold).