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Ontogeny of lgG2 Antibodies against S. aureus Teichoic Acid in Normal and Immunodeficient Children
Author(s) -
HAMMARSTRÖM L.,
GRANSTRÖM M.,
MÖLLBY R.,
OXELIUS V.,
PERSSON M. A. A.,
SMITH C. I. E.
Publication year - 1985
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1985.tb10933.x
Subject(s) - teichoic acid , medicine , antibody , ontogeny , microbiology and biotechnology , immunology , staphylococcus aureus , bacteria , biology , genetics
. Anti‐teichoic acid antibodies of various subclasses were found to be effectively transported across the placenta during pregnancy. In adults these antibodies are mainly of the IgG2 subclass although substantial amounts of specific IgGl antibodies may also be found. During ontogeny, specific IgGl antibodies develop during the second year of life whereas specific IgG2 antibodies appear markedly later. In IgG2 deficient children, prolonged deficiency of specific anti‐teichoic acid antibodies was observed, suggesting a lack of maturation of the appropriate idiotype(s). In children who received a bone marrow transplant from adult donors, engraftment of IgG2 producing cells could be seen, thus transferring the ability to produce specific antibodies.