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The Influence of Long‐term Cimetidine as an Adjuvant to Pancreatic Enzyme Therapy in Cystic Fibrosis
Author(s) -
CHALMERS D. M.,
BROWN R. C.,
MILLER M. G.,
CLARKE P. C. N.,
KELLEHER J.,
LITTLEWOOD J. M.,
LOSOWSKY M. S.
Publication year - 1985
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1985.tb10930.x
Subject(s) - medicine , cimetidine , placebo , cystic fibrosis , pancreatic enzymes , gastroenterology , pancreatic disease , vitamin , endocrinology , albumin , zoology , pancreas , pathology , alternative medicine , biology
. Seventeen patients on constant doses of pancreatic enzymes were randomised to receive either cimetidine or placebo for either of two successive six month periods. Nutritional state and maldigestion were assessed at the beginning and end of each period. Reductions in mean values of faecal fat, nitrogen, wet weight, and bile salts of approximately 30 % were found on cimetidine therapy. Results showed considerable variation and only the fall in faecal fat was statistically significant. No benefit was demonstrated for height, weight, skinfold thickness, albumin, vitamin A, bone age or Crispin‐Norman score.