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Mechanisms of Pancreatic B‐Cell Degeneration during the Course of Insulin‐dependent Diabetes Mellitus
Author(s) -
SANDLER STELLAN,
WELSH NILS
Publication year - 1985
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1985.tb10131.x
Subject(s) - medicine , diabetes mellitus , insulin , degeneration (medical) , endocrinology , pathology
. This paper presents a review of different mechanisms possibly responsible for the degeneration of the pancreatic B‐cell in insulin‐dependent diabetes mellitus. The genetic dependence probably located in the HLA DR‐locus of the sixth chromosome and its role in an autoimmune reaction against antigenieally altered pancreatic B‐cells is discussed. The actions of alloxan and streptozotacin in the induction of experimental diabetes, as models for postulated human B‐cytotoxins, are described.