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Apolipoproteins and Lipoproteins in Children with Type I Diabetes: Relation to Glycosylated Serum Protein and HbA 1
Author(s) -
STROBL W.,
WIDHALM K.,
SCHOBER E.,
FRISCH H.,
POLLAK A.,
WESTPHAL G.
Publication year - 1985
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1985.tb10066.x
Subject(s) - medicine , endocrinology , diabetes mellitus , lipoprotein , cholesterol , apolipoprotein b , very low density lipoprotein , metabolic control analysis , blood lipids
.Serum levels of cholesterol (C), triglycerides (TG), lipoprotein‐C and apolipoproteins (apo) A‐I, A‐II and B were measured in 30 children with type I diabetes mellitus (16 boys, 14 girls, aged 11–14 years) and in 26 healthy controls (15 boys, 11 girls, aged 10–13 years). For 19 diabetics controls matched for age, sex and relative body weight were selected. The diabetic patients were considered to be in fair metabolic control according to HbA 1 levels and glycosylated serum protein concentrations. Mean serum apo A‐I, A‐II and B, C, TG, low density lipoprotein cholesterol (LDL‐C) and high density lipoprotein cholesterol (HDL‐C) did not differ significantly between diabetic and nondiabetic children. Very low density lipoprotein cholesterol (VLDL‐C) was significantly higher in diabetic children than in controls. Serum C and LDL‐C levels showed close univariate linear correlations with glycosylated serum protein (LDL‐C: r =0.53, p <0.01, C: r =0.58, p <0.01) in diabetics. The ratio LDL/HDL‐C was significantly correlated to HbA 1 levels ( r =0.47, p <0.01). By canonical and multiple linear correlation analysis significant relations of a selected set of variables concerning the control and therapy of diabetes (serum glucose, HbA 1 , glycosylated serum protein, insulin dose) with a set of lipoprotein variables (C, TG, VLDL‐C, HDL‐C, LDL‐C, apo A‐I, A‐II, B) could be demonstrated. From these data we conclude that significant relations between atherogenic serum lipids and lipoproteins (C, LDL‐C) and the degree of metabolic control exist in diabetic children, even in the absence of marked dyslipoproteinemia. The close relation of LDL‐C and total C with glycosylated serum protein in the diabetics might be due to glycosylation of LDL .