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Natural Killer Activity in Two Cases of Ataxia Telangiectasia
Author(s) -
KASHIWA H.,
KISHI T.,
KITTAKA E.,
HYODO S.,
KARAKAWA T.,
OKADA M.,
MATSUSHITA T.,
MATSUURA R.,
SAKANO T.,
SAWANO K.,
USUI T.
Publication year - 1985
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1985.tb10042.x
Subject(s) - ataxia telangiectasia , medicine , phytohaemagglutinin , monoclonal , immunology , ataxia , natural killer cell , monoclonal antibody , antibody , lymphocyte , biochemistry , biology , cytotoxicity , dna , dna damage , psychiatry , in vitro
.We report two cases of ataxia telangiectasia in which a small number of T cells and a slightly diminished response to phytohaemagglutinin or concanavalin A were observed. In one case, serum IgA was undetectable. In spite of T and/or B cell involvement, natural killer activity and the percentage of natural killer cells determined by monoclonal antibodies Leu 7 were normal in both cases.