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Evaluation of an Oral Rehydration Solution with Na + 60 mmol/l in Infants Hospitalized for Acute Diarrhoea or Treated as Outpatients
Author(s) -
ISOLAURI ERIKA
Publication year - 1985
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1985.tb10005.x
Subject(s) - medicine , dehydration , ambulatory , diarrhea , sodium , oral rehydration therapy , high sodium , isotonic , pediatrics , gastroenterology , anesthesia , population , biochemistry , chemistry , environmental health , organic chemistry , blood pressure , health services
.An oral rehydration solution (ORS) containing 60 mmol/l of Na'(ORS 60 ) was compared in a randomized trial with the ORS of WHO formula (Na + 90 mmol/l = ORS 90 ) for the treatment of diarrhoeal dehydration in 66 hospitalized infants aged 3 to 34 months. The infants had a 5±3 % dehydration, and received within 6–10 hours 76±32 ml/kg of ORS 60 or 74±41 ml/kg of ORS 90 corresponding to a sodium input of 4.6±1.9 mmol/kg and 6.6±3.7 mmol/kg, respectively. Both treatments were found adequate and equally effective for the correction of dehydration and sodium deficit. The same ORS M was also compared to a commercial low sodium glucose‐electrolyte solution (sodium 35 mmol/l, glucose 3.5 g/1) for ambulatory treatment of acute diarrhoea in infants. Satisfactory rehydration was achieved within 6 hours in 19 of 23 infants receiving ORS 60 as opposed to 6 of 18 infants receiving the commercial solution (p<0.001); the poor result with the latter was in most cases attributed to a refusal by the infant to consume the sweetish solution. It is concluded that ORS 60 is suitable for the treatment of isotonic diarrhoeal dehydration in hospitalized children as well as outpatients.