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Longitudinal Study of Calcium Metabolism in Male Puberty
Author(s) -
KRABBE S.,
HUMMER L.,
CHRISTIANSEN C.
Publication year - 1984
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1984.tb17770.x
Subject(s) - endocrinology , medicine , androstenedione , testosterone (patch) , alkaline phosphatase , calcium , metabolism , androgen , biology , hormone , enzyme , biochemistry
. Height velocity, bone mineral content (BMC), serum concentrations of alkaline phosphatase (AP), testosterone, dehydroepiandrosterone (DHEA) and androstenedione (A‐dione) were determined as a part of a longitudinal study of calcium metabolism in normal male puberty. The time of maximal increase ( T m ) in concentrations was calculated for 20 boys from a curve‐fitting analysis program. Highly significant correlations were found between T m testosterone and T m BMC ( r =0.73, p<0.001); T m AP and T m BMC ( r =0.68, p <0.001). The mean difference in time between T m testosterone and T m BMC was 4.7 months and between T m AP and T m testosterone 0.7 month. Our data indicate a very close relationship between testosterone, osteoblastic activity, and mineralization in normal male puberty, whereas the adrenal androgens do not seem to have a major influence on the mineralization at the male puberty growth spurt phase.