Premium
Insulin Resistance in an Infant with Leprechaunism
Author(s) -
KASHIWA H.,
KAWAGUCHI S.,
TAKEDA M.,
KOBAYASHI M.,
OMORI Y.,
ETO R.
Publication year - 1984
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1984.tb10000.x
Subject(s) - medicine , insulin resistance , pediatrics , infant feeding , insulin , intensive care medicine , endocrinology , breast feeding
A Japanese female infant with typical features of leprechaunism exhibited glucose intolerance despite marked hyperinsulinemia, indicating insulin resistance. Circulating insulin appeared to be chemically and biologically norma). There was no evidence of antagonism of insulin action or circulating antibodies to insulin or insulin receptors. Insulin receptor assay of her erythrocytes showed very low affinity despite a six‐fold increase in the number of receptors as compared with those of normal adult controls. Our studies indicate that insulin resistance in this patient appears to be due to a qualitative abnormality of insulin receptors or to a postreceptor defect