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Aldosterone Concentrations in Dehydrated Infants
Author(s) -
PASSWELL J.,
RIGLER S.,
ALADJEM M.,
BOICHIS H.,
WAGNER I.,
ESHKOL A.
Publication year - 1984
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1984.tb09910.x
Subject(s) - aldosterone , hyperkalemia , medicine , endocrinology , sodium , potassium , chemistry , organic chemistry
. The mean serum aldosterone concentration of 37 infants with acute gastroenteritis and dehydration was markedly elevated on admission (mean ±SE 94.3±12.1 ng/ml) and approximated to normal values (18.2±3.7 ng/ml) following recovery from the acute disease (t=3.56 p<0.005). Serum aldosterone levels were significantly positively correlated with the percent weight loss (r=0.41, p<0.05) and with the blood urea nitrogen levels (r=0.55, p<0.001). There was no correlation between either serum sodium levels or blood osmolarity and aldosterone concentrations. Serum potassium levels were positively correlated with aldoster‐one levels (r=0.53, p<0.001). These findings indicate that small infants when dehydrated respond appropriately with elevated aldosterone levels. The amount of body fluid depletion and hyperkalemia are the major factors determining the amount of aldosterone response.