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The Dosage Dependency of Growth and Maturity in Growth Hormone Deficiency Treated with Human Growth Hormone
Author(s) -
VICENSCALVET E.,
VENDRELL J. M.,
ALBISU M.,
POTAU N.,
AUDI L.,
GUSINE M.
Publication year - 1984
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1984.tb09909.x
Subject(s) - medicine , hormone , endocrinology , growth hormone , human growth hormone , growth velocity , bone age , growth hormone deficiency , physiology
. A group of 11 pre‐pubertal growth hormone deficient patients were treated with human growth hormone over a period of 4 years. In 6 of the patients the dosage was 4 IU 3 times a week and in 5, 8 IU 3 times a week. Changes in height demonstrated that the “catch up” was significantly greater and of longer duration in the second group. In spite of a more rapid increase of bone age in the second group, the prognosis of final height had improved significantly at the end of the study period. A comparative study of the plasma concentrations of T4, T SH, gonadotrophins and steroids, to see if the greater velocity of bone maturity in the second group could be due to contamination of the preparation by other could be due to contamination of the preparation by other hypophysary hormones, did not demonstrate significant differences between the groups.