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THE EFFECT OF VITAMIN E ON ERYTHROCYTE HEMOLYSIS AND LIPID PEROXIDATION IN NEWBORN PREMATURE INFANTS
Author(s) -
CRUZ CARINA S. D.,
WIMBERLEY P. D.,
JOHANSEN K.,
FRIISHANSEN B.
Publication year - 1983
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1983.tb09823.x
Subject(s) - hemolysis , medicine , vitamin e , lipid peroxide , cord blood , lipid peroxidation , vitamin , tocopherol , physiology , endocrinology , antioxidant , biochemistry , biology , oxidative stress
. The biochemical effect of vitamin E supplementation to mothers with threatened premature delivery and to premature infants after birth has been studied. Although a weak correlation was found between maternal and cord blood vitamin E levels at birth, cord blood levels were not significantly higher in the infants from supplemented mothers than those from unsupplemented mothers. Furthermore, maternal vitamin E treatment did not prevent either erythrocyte hemolysis or lipid peroxide formation in the premature infants after birth. On the other hand, intramuscular vitamin E to infants after birth produced a marked biochemical effect, with both zero erythrocyte hemolysis and low lipid peroxide formation when serum vitamin E increased above 2 mg/100 ml. We conclude that intramuscular vitamin E immediately after birth is necessary to achieve a biochemical effect of vitamin E in the early neonatal period. (No cases of retrolental fibroplasia occurred in the present study.)