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A CASE OF IMMUNODEFICIENCY WITH DECREASED SERUM IgA LEVELS AND IMPAIRED POLYCLONAL B CELL DIFFERENTIATION IN VITRO
Author(s) -
SAKANO T.,
HOSOKAWA A.,
HORINO N.,
HYODO S.,
KISHI T.,
SUZAWA T.,
KITTAKA E.,
SAKURA N.,
USUI T.
Publication year - 1983
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1983.tb09818.x
Subject(s) - polyclonal antibodies , medicine , immunology , in vitro , antibody , immunodeficiency , b cell , iga deficiency , immunoglobulin m , immunoglobulin a , immunoglobulin g , immune system , biology , biochemistry
. We report a patient with low serum IgA levels and persistent pulmonary infection. In spite of the normal contents of serum IgG and IgM, the patient had a deficiency for plasma cell differentiation of all major classes of immunoglobulins (IgG, IgA and IgM). Cross culture systems between normal T or B cells and the patient's T or B cells showed a defect of both T and B cell function.