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SEQUENTIAL DETERMINATION OF CRP, α 1 ‐ANTITRYPSIN AND HAPTOGLOBIN IN NEONATAL SEPTICAEMIA
Author(s) -
SPEER CH.,
BRUNS A.,
GAHR M.
Publication year - 1983
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1983.tb09793.x
Subject(s) - medicine , haptoglobin , c reactive protein , intensive care medicine , pediatrics , immunology , inflammation
. In 312 preterm and term newborn infants serum concentrations of C‐reactive protein (CRP), haptoglobin and α 1 ‐antitrypsin were measured during several days by radial immunodiffusion. In addition white blood cell count and the ratio of band to total neutrophils (B/N‐ratio) were determined. In 12 infants with proven sepsis CRP was found elevated above the upper limit of the normal range (20 mg/l). Successful therapy was followed by a decrease of CRP concentration. In infants with suspected infection high CRP values were found in most cases. In contrast, haptoglobin and α 1 ‐antitrypsin concentrations differed not significantly between the group of infants without infection, with proven and with suspected infection. White blood cell count and B/N‐ratio also were not appropriate for the early identification of bacterial infection in the newborn period.