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ELEVATION OF LIPID PEROXIDE IN CHILDREN TREATED WITH A COMBINATION OF CHEMOTHERAPEUTIC AGENTS INCLUDING DOXORUBICIN
Author(s) -
HORINO NOBUKO,
KOBAYASHI YOHNOSUKE,
USUI TOMOFUSA
Publication year - 1983
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1983.tb09769.x
Subject(s) - medicine , doxorubicin , lipid peroxide , pharmacology , peroxide , chemotherapeutic drugs , elevation (ballistics) , chemotherapy , oxidative stress , lipid peroxidation , chemistry , organic chemistry , geometry , mathematics
. The fluorometric method of Yagi was used to determine serum lipid peroxide levels in children with various types of malignancies, treated with or without doxorubicin. It was found that patients on regimens of intermittent combination chemotherapies including doxorubicin had higher levels of serum lipid peroxide and were all apparently free from cardiotoxicity. Doxorubicin was the only determinant in affecting the serum lipid peroxide value. Coenzyme Q 10 given concurrently failed to reduce the elevated levels to normal.