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PLASMA AND ERYTHROCYTE ZINC, COPPER AND SELENIUM IN CYSTIC FIBROSIS
Author(s) -
NEVE J.,
GEFFEL R. VAN,
HANOCQ M.,
MOLLE L.
Publication year - 1983
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1983.tb09743.x
Subject(s) - selenium , zinc , glutathione peroxidase , medicine , cystic fibrosis , endocrinology , superoxide dismutase , copper , chemistry , oxidative stress , organic chemistry
. Plasma and erythrocyte zinc, copper and selenium were measured in 20 cystic fibrosis children, aged 7 to 19 years. Mean plasma zinc and copper levels were not different from those in age‐matched controls but very low zinc levels occurred sporadically. Plasma zinc concentrations were significantly lower in patients with moderate‐to‐severe growth retardation and with severe pulmonary disease as compared to patients without growth failure and with moderate pulmonary disease. Mean erythrocyte zinc (40.8 μg/g Hb ±9.2) and copper levels (3.56 μg/g Hb ±0.50) were very significantly increased (30.4 μg/g Hb ±5.2 and 2.73 μg/g Hb ±0.30 respectively, for age‐matched controls). Mean plasma and erythrocyte selenium levels (63 ng/ml ±15 and 329 ng/g Hb ±86) were significantly lower than those in age‐matched controls (82 ng/ml ±13 and 404 ng/g Hb ±116). The trace element concentrations in erythrocytes are discussed in relation to the activities of the copper‐ and zinc‐containing enzyme superoxide dismutase and the seleno‐enzyme glutathione peroxidase. We consider that more data on trace element metabolism in CF should be collected before specific supplementation is considered.